Cannabigerol (CBG)
CBG is often referred to as the "mother of all cannabinoids," and for good reason. This important compound is the precursor or “Mama” to many other cannabinoids. Like so many other Mamas who often don’t get the credit they’re due, CBG has been overshadowed by its more famous "children," CBD and THC. However, CBG may be having a moment because recent research has begun to shed light on its unique properties and potential therapeutic benefits.
What Exactly is CBG?
CBG is a non-intoxicating cannabinoid found in cannabis plants. In its acidic form (CBGA), it serves as the starting point for the synthesis of other major cannabinoids. As cannabis plants mature, most CBGA is converted into other compounds such as THCA and CBDA (the acidic forms of THC and CBD), leaving only small amounts of CBG in the mature cannabis plant. However, breeders have recently developed CBG-dominant strains, making this cannabinoid more accessible for research and consumption.
Potential CBG Benefits
Although research on CBG is still in its early stages, preclinical studies and anecdotal evidence suggest several potential benefits.
Stress and Anxiety Relief: CBG has shown promise in reducing anxiety-like behaviors in animal studies. It may interact with the brain's serotonin and GABA systems, potentially offering anxiolytic effects.
Pain Management: CBG demonstrates analgesic properties in preclinical trials, particularly for inflammatory pain. Its interaction with alpha-2 adrenoreceptors may contribute to its pain-relieving effects.
Anti-inflammatory Effects: Studies suggest CBG may have potent anti-inflammatory effects, which could benefit conditions like inflammatory bowel disease.
Neuroprotection: CBG has shown neuroprotective effects in studies, potentially benefiting neurodegenerative conditions.
Antibacterial Effects: CBG has demonstrated impressive antibiotic activity, particularly against antibiotic-resistant bacteria like MRSA.
Appetite Stimulation: CBG may stimulate appetite without psychoactive effects, potentially benefiting those with eating disorders or undergoing treatments that suppress appetite.
What Users of CBG Say
A survey of CBG users (Russo et al 2021) revealed some interesting findings:
People mainly use CBG for anxiety, chronic pain, and depression.
Many found CBG more effective than traditional medications for these conditions.
Some users were able to reduce or stop using pharmaceutical pain medications.
CBG was generally well-tolerated, with only mild side effects reported by a few users.
While these findings are promising, it's important to note that more rigorous clinical trials are needed to fully understand CBG's effects and potential therapeutic uses in humans.
Final Thoughts
As research into CBG continues to expand, we're likely to gain a deeper understanding of this intriguing cannabinoid and its potential applications. As always, individuals interested in using CBG should consult with a healthcare professional knowledgeable about cannabis-based treatments.
Stay tuned for more updates on CBG and other emerging cannabinoids as we continue to explore the fascinating world of cannabis science!
References
Cuttler, C., Stueber, A., Cooper, Z. D., & Russo, E. (2024). Acute effects of cannabigerol on anxiety, stress, and mood: A double-blind, placebo-controlled, crossover, field trial. Scientific Reports, 14, 16163. https://doi.org/10.1038/s41598-024-66879-0
de Meijer, E. P. M., & Hammond, K. M. (2005). The inheritance of chemical phenotype in Cannabis sativa L. (II): Cannabigerol predominant plants. Euphytica, 145, 189–198. https://doi.org/10.1007/s10681-005-1164-8
Russo, E. B., Cuttler, C., Cooper, Z. D., Stueber, A., Whiteley, V. L., & Sexton, M. (2021). Survey of patients employing cannabigerol-predominant cannabis preparations: Perceived medical effects, adverse events, and withdrawal symptoms. Cannabis and Cannabinoid Research, 7(5). https://doi.org/10.1089/can.2021.0058
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